Recent Publications
A Functional Selectivity Mechanism at the Serotonin-2A GPCR Involves Ligand-Dependent Conformations of Intracellular Loop 2 J Am Chem Soc, Oct 2014
Conformational changes in dopamine transporter intracellular regions upon cocaine binding and dopamine translocation. Neurochemistry International, Jul 2014
Missense dopamine transporter mutations associate with adult parkinsonism and ADHD J Clin Invest, Jul 2014
Not Just an Oil Slick: How the Energetics of Protein-Membrane Interactions Impacts the Function and Organization of Transmembrane Proteins Biophys J, Jun 2014
PIP2 regulates psychostimulant behaviors through its interaction with a membrane protein Nat Chem Biol, Jun 2014
Conformational dynamics of ligand-dependent alternating access in LeuT Nat Struct Mol Biol, May 2014
NbIT – A New Information Theory-Based Analysis of Allosteric Mechanisms Reveals Residues that Underlie Function in the Leucine Transporter LeuT PLoS Comp Biol, May 2014
Protein and Lipid Interactions Driving Molecular Mechanisms of in meso Crystallization. J Am Chem Soc, Feb 2014
How the Dynamic Properties and Functional Mechanisms of GPCRs Are Modulated by Their Coupling to the Membrane Environment Adv Exp Med Biol, Jan 2014
Membrane Driven Spatial Organization of GPCRs Nat Sci Rep, Oct 2013
A modeling framework for deriving the structural and functional architecture of a short-term memory microcircuit Neuron, Sep 2013
The Membrane Protein LeuT in Micellar Systems: Aggregation Dynamics and Detergent Binding to the S2 Site J Am Chem Soc, Jun 2013
Chloride binding site of neurotransmitter sodium symporters PNAS, May 2013
The cost of living in the membrane: A case study of hydrophobic mismatch for the multi-segment protein LeuT Chem Phys Lip, Apr 2013
Steric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporter J Biol Chem, Nov 2012
Computational modeling reveals dendritic origins of GABA(A)-mediated excitation in CA1 pyramidal neurons PLoS One, Oct 2012
In support of the BMRB Nat Struct Mol Biol, Sep 2012
Ion-Controlled Conformational Dynamics in the Outward-Open Transition from an Occluded State of LeuT Biophys J, Sep 2012
Phosphatidylinositol 4,5-Biphosphate (PIP(2)) Lipids Regulate the Phosphorylation of Syntaxin N-Terminus by Modulating Both Its Position and Local Structure Biochem, Sep 2012
Why GPCRs behave differently in cubic and lamellar lipidic mesophases J Am Chem Soc, Sep 2012
Multiple SNPs in intron 41 of thyroglobulin gene are associated with autoimmune thyroid disease in the Japanese population PLoS One, May 2012
Structural Intermediates in a Model of the Substrate Translocation Path of the Bacterial Glutamate Transporter Homologue GltPh J Phys Chem B, May 2012
Identification of functionally active, low frequency copy number variants at 15q21.3 and 12q21.31 associated with prostate cancer risk PNAS, Apr 2012
Ligand-Dependent Conformations and Dynamics of the Serotonin 5-HT(2A) Receptor Determine Its Activation and Membrane-Driven Oligomerization Properties PLoS Comp Biol, Apr 2012
The Clathrin Adaptor AP-1A Mediates Basolateral Polarity Dev Cell, Apr 2012
Dipole characterization of single neurons from their extracellular action potentials J Comput Neurosci, Feb 2012
Experimental conditions can obscure the second high-affinity site in LeuT Nat Struct Mol Biol, Jan 2012
Interactions of the Cell Membrane with Integral Proteins Comprehensive Biophysics, Vol. 9, Jan 2012
The correlation between multidomain enzymes and multiple activation mechanisms–the case of phospholipase Cβ and its membrane interactions Biochim Biophys Acta., Dec 2011
Determination of awareness in patients with severe brain injury using EEG power spectral analysis Clin Neurophysiol, Nov 2011
Quantitative modeling of membrane deformations by multihelical membrane proteins: application to G-protein coupled receptors Biophys J, Nov 2011
A dynamic model of membrane-bound phospholipase Cβ2 activation by Gβγ subunits Mol Pharmacol, Sep 2011
High-Resolution 3D Reconstruction Reveals Intra-Synaptic Amyloid Fibrils Am J Pathol, Sep 2011
Mean-field modeling of thalamocortical dynamics and a model-driven approach to EEG analysis PNAS, Sep 2011
Novel variant of thyroglobulin promoter triggers thyroid autoimmunity through an epigenetic interferon alpha-modulated mechanism J Biol Chem, Sep 2011
Spatial gradients and multidimensional dynamics in a neural integrator circuit Nat Neurosci, Aug 2011
Volumetric three-dimensional reconstruction and segmentation of spectral-domain OCT Ophthalmic Surg Lasers Imaging, Jul 2011
Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homolog Nature, Jun 2011
Three-dimensional reconstruction and analysis of vitreomacular traction: quantification of cyst volume and vitreoretinal interface area Arch Ophthalmol, Jun 2011
Temporal coding of taste in the parabrachial nucleus of the pons of the rat J Neurophysiol, Apr 2011
Information-geometric measure of 3-neuron firing patterns characterizes scale-dependence in cortical networks J Comput Neurosci, Feb 2011
Regression-based identification of behavior-encoding neurons during large-scale optical imaging of neural activity at cellular resolution J Neurophysiol, Feb 2011
Temporal coding of intensity of NaCl and HCl in the nucleus of the solitary tract of the rat J Neurophysiol, Feb 2011
Aberrant DNA hypermethylation signature in acute myeloid leukemia directed by EVI1 Blood, Jan 2011
PDZ Binding to the BAR Domain of PICK1 is Elucidated by Coarse-grained Molecular Dynamics J Mol Biol, Jan 2011
The binding sites for benztropines and dopamine in the dopamine transporter overlap Neuropharm, Jan 2011
The substrate-driven transition to an inward-facing conformation in the functional mechanism of the dopamine transporter PLoS One, Jan 2011