TiSimilarity Example

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queryAccessionCode	targetAccessionCode	score	rank	queryNonZeroTissueCount	targetNonZeroTissueCount
ENST00000346798	ENST00000346798	2326.0	1	85	85	1
ENST00000346798	ENST00000358918	2314.0	2	85	86	3
ENST00000346798	ENST00000357903	2314.0	2	85	85	3
ENST00000346798	ENST00000359726	2259.0	3	85	85	4
ENST00000346798	ENST00000348990	2255.0	4	85	85	5
ENST00000346798	ENST00000354192	2215.0	5	85	85	6
ENST00000346798	ENST00000216281	2050.0	6	85	98	8
ENST00000346798	ENST00000334701	2050.0	6	85	98	8
ENST00000346798	ENST00000376781	1987.0	7	85	97	9
ENST00000346798	ENST00000227378	1975.0	8	85	97	10
ENST00000346798	ENST00000339647	1965.0	9	85	98	11
ENST00000346798	ENST00000339545	1899.0	10	85	97	12
ENST00000346798	ENST00000325925	1879.0	11	85	100	14
ENST00000346798	ENST00000267115	1879.0	11	85	94	14
ENST00000346798	ENST00000263574	1849.0	12	85	86	15
ENST00000346798	ENST00000278756	1840.0	13	85	86	16
ENST00000346798	ENST00000225792	1839.0	14	85	95	17
ENST00000346798	ENST00000338167	1838.0	15	85	86	18
ENST00000346798	ENST00000358528	1823.0	16	85	92	19
ENST00000346798	ENST00000359892	1811.0	17	85	95	20

Annotating this list (e.g., with biomart) yields:

Score Ensembl Gene ID	Ensembl Transcript ID	Description
234.0 ENSG00000142192	ENST00000357903	Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer disease amyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (Protease nexin-II) (PN-II) (APPI) (PreA4) [Contains: Soluble APP-alpha (S-APP- alpha); Soluble APP-beta (S-APP-beta); C99; Beta- [Source:Uniprot/SWISSPROT;Acc:P05067]
234.0 ENSG00000142192	ENST00000346798	Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer disease amyloid protein) (Cerebral  vascular amyloid peptide) (CVAP) (Protease nexin-II) (PN-II) (APPI) (PreA4) [Contains: Soluble APP-alpha (S-APP- alpha); Soluble APP-beta (S-APP-beta); C99; Beta- [Source:Uniprot/SWISSPROT;Acc:P05067]
231.0 ENSG00000142192	ENST00000358918	Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer disease amyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (Protease nexin-II) (PN-II) (APPI) (PreA4) [Contains: Soluble APP-alpha (S-APP- alpha); Soluble APP-beta (S-APP-beta); C99; Beta- [Source:Uniprot/SWISSPROT;Acc:P05067]
231.0 ENSG00000142192	ENST00000348990	Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer disease amyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (Protease nexin-II) (PN-II) (APPI) (PreA4) [Contains: Soluble APP-alpha (S-APP- alpha); Soluble APP-beta (S-APP-beta); C99; Beta- [Source:Uniprot/SWISSPROT;Acc:P05067]
231.0 ENSG00000142192	ENST00000359726	Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer disease amyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (Protease nexin-II) (PN-II) (APPI) (PreA4) [Contains: Soluble APP-alpha (S-APP- alpha); Soluble APP-beta (S-APP-beta); C99; Beta- [Source:Uniprot/SWISSPROT;Acc:P05067]
230.0 ENSG00000142192	ENST00000354192	Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer disease amyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (Protease nexin-II) (PN-II) (APPI) (PreA4) [Contains: Soluble APP-alpha (S-APP- alpha); Soluble APP-beta (S-APP-beta); C99; Beta- [Source:Uniprot/SWISSPROT;Acc:P05067]
196.0 ENSG00000139644	ENST00000267115	Bax inhibitor 1 (BI-1) (Testis-enhanced gene transcript) (Transmembrane BAX inhibitor motif-containing protein 6). [Source:Uniprot/SWISSPROT;Acc:P55061]
196.0 ENSG00000026025	ENST00000359892	Vimentin. [Source:Uniprot/SWISSPROT;Acc:P08670]
195.0 ENSG00000108654	ENST00000225792	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase   
194.0 ENSG00000026025	ENST00000224237	Vimentin. [Source:Uniprot/SWISSPROT;Acc:P08670]p68). [Source:Uniprot/SWISSPROT;Acc:P17844]
193.0 ENSG00000080824	ENST00000334701	Heat shock protein HSP 90-alpha (HSP 86) (Renal carcinoma antigen NY- REN-38). [Source:Uniprot/SWISSPROT;Acc:P07900]
193.0 ENSG00000009307	ENST00000358528	GTPase NRas precursor (Transforming protein N-Ras). [Source:Uniprot/SWISSPROT;Acc:P01111]
193.0 ENSG00000080824	ENST00000216281	Heat shock protein HSP 90-alpha (HSP 86) (Renal carcinoma antigen NY- REN-38).  [Source:Uniprot/SWISSPROT;Acc:P07900]
192.0 ENSG00000150991	ENST00000339545	Ubiquitin. [Source:Uniprot/SWISSPROT;Acc:P62988]
192.0 ENSG00000150991	ENST00000339647	Ubiquitin. [Source:Uniprot/SWISSPROT;Acc:P62988]
192.0 ENSG00000096384	ENST00000343988	Heat shock protein HSP 90-beta (HSP 84) (HSP 90). [Source:Uniprot/SWISSPROT;Acc:P08238]
192.0 ENSG00000150991	ENST00000376781	Ubiquitin. [Source:Uniprot/SWISSPROT;Acc:P62988]
191.0 ENSG00000096384	ENST00000353801	Heat shock protein HSP 90-beta (HSP 84) (HSP 90). [Source:Uniprot/SWISSPROT;Acc:P08238]
191.0 ENSG00000096384	ENST00000371554	Heat shock protein HSP 90-beta (HSP 84) (HSP 90). [Source:Uniprot/SWISSPROT;Acc:P08238]
191.0 ENSG00000096384	ENST00000371646	Heat shock protein HSP 90-beta (HSP 84) (HSP 90). [Source:Uniprot/SWISSPROT;Acc:P08238]

It is interesting to note that a temporal similarity between the expression profiles of APP and vimentin has been reported (Durham HD et al 1994).

Durham, H D, Minotti, S, Dooley, N P, et al. Expression of the intermediate filament-associated protein related to beta-amyloid precursor protein is developmentally regulated in cultured cells. J Neurosci Res 38 (1994 Aug 15): 629-39.[[1]]

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