# P-values

### From Icbwiki

A P-value associated to a result is the estimate of how likely the result could be observed by chance alone. P-values are preferable to unnormalized scores because users can determine the amout of risk they are willing to take in looking (and following up) with the matches.

There are many publications about P-value calculations for alignment-based similarity search methods. This is a very partial list:

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