TiSimilarity Example
From Icbwiki
queryAccessionCode targetAccessionCode score rank queryNonZeroTissueCount targetNonZeroTissueCount ENST00000346798 ENST00000346798 2326.0 1 85 85 1 ENST00000346798 ENST00000358918 2314.0 2 85 86 3 ENST00000346798 ENST00000357903 2314.0 2 85 85 3 ENST00000346798 ENST00000359726 2259.0 3 85 85 4 ENST00000346798 ENST00000348990 2255.0 4 85 85 5 ENST00000346798 ENST00000354192 2215.0 5 85 85 6 ENST00000346798 ENST00000216281 2050.0 6 85 98 8 ENST00000346798 ENST00000334701 2050.0 6 85 98 8 ENST00000346798 ENST00000376781 1987.0 7 85 97 9 ENST00000346798 ENST00000227378 1975.0 8 85 97 10 ENST00000346798 ENST00000339647 1965.0 9 85 98 11 ENST00000346798 ENST00000339545 1899.0 10 85 97 12 ENST00000346798 ENST00000325925 1879.0 11 85 100 14 ENST00000346798 ENST00000267115 1879.0 11 85 94 14 ENST00000346798 ENST00000263574 1849.0 12 85 86 15 ENST00000346798 ENST00000278756 1840.0 13 85 86 16 ENST00000346798 ENST00000225792 1839.0 14 85 95 17 ENST00000346798 ENST00000338167 1838.0 15 85 86 18 ENST00000346798 ENST00000358528 1823.0 16 85 92 19 ENST00000346798 ENST00000359892 1811.0 17 85 95 20
Annotating this list (e.g., with biomart) yields:
Score Ensembl Gene ID Ensembl Transcript ID Description 234.0 ENSG00000142192 ENST00000357903 Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer disease amyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (Protease nexin-II) (PN-II) (APPI) (PreA4) [Contains: Soluble APP-alpha (S-APP- alpha); Soluble APP-beta (S-APP-beta); C99; Beta- [Source:Uniprot/SWISSPROT;Acc:P05067] 234.0 ENSG00000142192 ENST00000346798 Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer disease amyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (Protease nexin-II) (PN-II) (APPI) (PreA4) [Contains: Soluble APP-alpha (S-APP- alpha); Soluble APP-beta (S-APP-beta); C99; Beta- [Source:Uniprot/SWISSPROT;Acc:P05067] 231.0 ENSG00000142192 ENST00000358918 Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer disease amyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (Protease nexin-II) (PN-II) (APPI) (PreA4) [Contains: Soluble APP-alpha (S-APP- alpha); Soluble APP-beta (S-APP-beta); C99; Beta- [Source:Uniprot/SWISSPROT;Acc:P05067] 231.0 ENSG00000142192 ENST00000348990 Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer disease amyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (Protease nexin-II) (PN-II) (APPI) (PreA4) [Contains: Soluble APP-alpha (S-APP- alpha); Soluble APP-beta (S-APP-beta); C99; Beta- [Source:Uniprot/SWISSPROT;Acc:P05067] 231.0 ENSG00000142192 ENST00000359726 Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer disease amyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (Protease nexin-II) (PN-II) (APPI) (PreA4) [Contains: Soluble APP-alpha (S-APP- alpha); Soluble APP-beta (S-APP-beta); C99; Beta- [Source:Uniprot/SWISSPROT;Acc:P05067] 230.0 ENSG00000142192 ENST00000354192 Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer disease amyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (Protease nexin-II) (PN-II) (APPI) (PreA4) [Contains: Soluble APP-alpha (S-APP- alpha); Soluble APP-beta (S-APP-beta); C99; Beta- [Source:Uniprot/SWISSPROT;Acc:P05067] 196.0 ENSG00000139644 ENST00000267115 Bax inhibitor 1 (BI-1) (Testis-enhanced gene transcript) (Transmembrane BAX inhibitor motif-containing protein 6). [Source:Uniprot/SWISSPROT;Acc:P55061] 196.0 ENSG00000026025 ENST00000359892 Vimentin. [Source:Uniprot/SWISSPROT;Acc:P08670] 195.0 ENSG00000108654 ENST00000225792 Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase 194.0 ENSG00000026025 ENST00000224237 Vimentin. [Source:Uniprot/SWISSPROT;Acc:P08670]p68). [Source:Uniprot/SWISSPROT;Acc:P17844] 193.0 ENSG00000080824 ENST00000334701 Heat shock protein HSP 90-alpha (HSP 86) (Renal carcinoma antigen NY- REN-38). [Source:Uniprot/SWISSPROT;Acc:P07900] 193.0 ENSG00000009307 ENST00000358528 GTPase NRas precursor (Transforming protein N-Ras). [Source:Uniprot/SWISSPROT;Acc:P01111] 193.0 ENSG00000080824 ENST00000216281 Heat shock protein HSP 90-alpha (HSP 86) (Renal carcinoma antigen NY- REN-38). [Source:Uniprot/SWISSPROT;Acc:P07900] 192.0 ENSG00000150991 ENST00000339545 Ubiquitin. [Source:Uniprot/SWISSPROT;Acc:P62988] 192.0 ENSG00000150991 ENST00000339647 Ubiquitin. [Source:Uniprot/SWISSPROT;Acc:P62988] 192.0 ENSG00000096384 ENST00000343988 Heat shock protein HSP 90-beta (HSP 84) (HSP 90). [Source:Uniprot/SWISSPROT;Acc:P08238] 192.0 ENSG00000150991 ENST00000376781 Ubiquitin. [Source:Uniprot/SWISSPROT;Acc:P62988] 191.0 ENSG00000096384 ENST00000353801 Heat shock protein HSP 90-beta (HSP 84) (HSP 90). [Source:Uniprot/SWISSPROT;Acc:P08238] 191.0 ENSG00000096384 ENST00000371554 Heat shock protein HSP 90-beta (HSP 84) (HSP 90). [Source:Uniprot/SWISSPROT;Acc:P08238] 191.0 ENSG00000096384 ENST00000371646 Heat shock protein HSP 90-beta (HSP 84) (HSP 90). [Source:Uniprot/SWISSPROT;Acc:P08238]
It is interesting to note that a temporal similarity between the expression profiles of APP and vimentin has been reported (Durham HD et al 1994).
Durham, H D, Minotti, S, Dooley, N P, et al. Expression of the intermediate filament-associated protein related to beta-amyloid precursor protein is developmentally regulated in cultured cells. J Neurosci Res 38 (1994 Aug 15): 629-39.[[1]]
