Campagne laboratory
 | [ research emphases ] |
Our laboratory develops computational methods and tools to facilitate new biological discoveries. We apply a variety of computational techniques, including data mining, visualization, information and knowledge management, machine learning and statistics to contribute to significant biomedical problems. The current focus of the lab is:
 | Reliable protocols for biomarker discovery and biomarker candidate model selection (in collaboration with the MAQC-II consortium). |
| TEPSS: Tissue Expression Profile Similarity Searches and application to the prioritization of candidate risk genes for neurodegenerative diseases (i.e., late onset-Alzheimer’s disease, in collaboration with Dr. Philippe Marambaud and prioritization of ataxia gene candidates). |
Previous projects:
| TissueInfo Mining of EST data for biomarker discovery. |
Furthermore, the lab participates in collaborations to develop:
| Ways to predict the selective site of cysteine S-Nitrosylation in proteins (Collaboration with Steven Gross at Weill Cornell who develops proteomics methods to identify sites of S-nitrosylation and provides the data used in the machine learning approach). |
| [ research opportunities in the laboratory ] |
Students enrolled in one of following Weill Cornell graduate programs can apply for rotations in the lab:
Other students interested in joining the laboratory are encouraged to apply to these programs and mention the laboratory in their application package.
| [ recent publications ] |
Dreses-Werringloer U, Lambert JC, Vingtdeux V, Zhao H, Vais H, Siebert A, Jain A, Koppel J, Rovelet-Lecrux A, Hannequin D, Pasquier F, Galimberti D, Scarpini E, Mann D, Lendon C, Campion D, Amouyel P, Davies P, Foskett JK, Campagne F, Marambaud P. A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk. Cell. 2008 Jun 27;133(7):1149-61. [PubMed]
Aguilar D, Skrabanek L, Gross SS, Oliva B, Campagne F. Beyond tissueInfo: functional prediction using tissue expression profile similarity searches. Nucleic Acids Res. 2008 Jun;36(11):3728-37. Epub 2008 May 15. [PubMed]
List of publications in PubMed.
Book chapters and other publications:
| Filizola M, Visiers I, Skrabanek L, Campagne F, Weinstein H. Functional mechanisms of GPCRs in a structural context. In Molecular Neuropharmacology, Strategies and Methods, Eds., A. Schousboe and H. Bräuner-Osborne, Humana Press. Dec. 2003, |
| Chan E, Campagne F,
Applications, Representation and Management of Signaling Pathway Information: Introduction to the SigPath Project. In Introduction to Systems Biology, chapter 19, Ed. Sangdun Choi, Humana Press. ISBN13: 978-1-58829-706-8 |
| Deng X, and Campagne F. Biomarker discovery and validation with high-throughput measurement technologies. Statistical Methods in Molecular Biology. Editors: Bang H, Zhou XK, Van Epps HL, Mazumdar M, Human Press, in press.
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