Trine Krogh-Madsen, PhD

Assistant Research Professor of Physiology in Medicine
Assistant Research Professor of Computational Biomedicine
Weill Cornell Medical College

Contact info
Weill Cornell Medical College
520 E. 70th St., Starr 463
New York, NY 10065
phone: 212-746-6275
fax: 212-746-8451


















WCMC Cardiology

Institute for Computational Biomedicine

Reseach areas

Cardiac electrophysiology, control of cardiac arrhythmias, mechanisms of arrhythmogenesis, nonlinear dynamics and bifurcations, computational biology.


Publications by topic

Atrial modeling

  • R. Kant, Z. Hu, J.K. Malhotra, T. Krogh-Madsen, D.J. Christini, P.M. Heerdt, G.W. Abbott.
    NHE isoform switching in aging porcine atria - a piece in the NHE1 inhibitor clinical trial failure puzzle?”.
    PLoS ONE, in press.
  • T. Krogh-Madsen, G.W. Abbott, and D.J. Christini.
    “Effects of Electrical and Structural Remodeling on Atrial Fibrillation Maintenance: A Simulation Study”.
    PLoS Comput Biol. E 8:e1002390021924, 2012, PMCID: PMC3285569.

Cell-transforming clamp

  • C.T. Bot, A.R. Kherlopian, F.A. Ortega, D.J. Christini, and T. Krogh-Madsen.
    “Rapid genetic algorithm optimization of a mouse computational model: benefits for anthropomorphization of neonatal mouse cardiomyocytes”.
    Front Physiol. 3:421, 2012, PMCID: PMC3488799.

Alternans and alternans control

  • S.A. Gaeta, T. Krogh-Madsen, and D.J. Christini.
    “Feedback-control induced pattern formation in cardiac myocytes: A mathematical modeling study”.
    J Theor Biol. 266:408-418, 2010, PMCID: PMC2927785.
  • T. Krogh-Madsen, A. Karma, M.L. Riccio, P.N. Jordan, D.J. Christini, and R.J. Gilmour, Jr.
    “Off-site control of repolarization alternans in cardiac fibers”.
    Phys Rev E 81:011915-1--8, 2010, PMCID: PMC2933068.
  • T. Krogh-Madsen and D.J. Christini.
    "Action potential duration dispersion and alternans in simulated heterogeneous cardiac tissue with a structural barrier”.
    Biophys J. 92:1138-1149, 2007.
  • T. Krogh-Madsen, P.N. Jordan, and D.J. Christini.
    "Control of Cardiac Electrical Nonlinear Dynamics".
    Handbook of Chaos Control, 2nd ed., Wiley, 2007.

Termination of cardiac reentry

  • T. Krogh-Madsen and D.J. Christini.
    “Pacing-induced spatiotemporal dynamics can be exploited to improve reentry termination efficacy”.
    Phys Rev E 80:021924-1--12, 2009.
  • T. Krogh-Madsen and D.J. Christini.
    “Resetting and termination of reentry in a loop-and-tail cardiac model”.
    Phys Rev E 77:011916-1--5, 2008.
  • T. Krogh-Madsen and D.J. Christini.
    "Termination of Cardiac Reentry".
    Proceedings of the 2008 Conference on Frontiers of Applied and Computational Mathematics, 2009.

Modeling cardiac action potential dynamics

  • A. Maoz, D.J. Christini, and T. Krogh-Madsen.
    "Dependence of phase-2 reentry and repolarization dispersion on epicardial and transmural ionic heterogeenity: a simulation study".
    Europace, in press.
  • T. Krogh-Madsen and D.J. Christini.
    "Nonlinear dynamics in cardiology".
    Annu Rev Biomed Eng. 14:179-203, 2012.
  • A. Maoz, T. Krogh-Madsen, and D.J. Christini.
    “Instability in action potential morphology underlies phase 2 reentry: A mathematical modeling study”.
    Heart Rhythm 6:813–822, 2009.
  • E. Gordon, G. Panaghie, L. Deng, K.J. Bee, T.K. Roepke, T. Krogh-Madsen, D.J. Christini, H. Ostrer, C.T. Basson, W. Chung, and G.W. Abbott.
    “A KCNE2 mutation in a patient with cardiac arrhythmia induced by auditory stimuli and serum electrolyte imbalance”.
    Cardiovasc Res. 77:98-106, 2008.
  • C. Lerma, T. Krogh-Madsen, M.R. Guevara, and L. Glass.
    “Stochastic aspects of cardiac arrhythmias".
    J Stat Phys. 128:347-374, 2007.
  • T. Krogh-Madsen, P. Schaffer, A.D. Skriver, L.K. Taylor, B. Pelzmann, B. Koidl, and M.R. Guevara.
    “An ionic model for rhythmic activity in small clusters of embryonic chick ventricular cells”.
    Am J Physiol (Heart & Circ) 289: H398-H413, 2005.
  • T. Krogh-Madsen, L. Glass, E.J. Doedel, and M.R. Guevara.
    “Discontinuities in the phase-resetting response of cardiac pacemakers”.
    J Theor Biol. 230:499-519, 2004.