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June 2015

Regulatory Variation from RNA to Protein in Humans and Primates

June 8, 2015 @ 2:00 pm - 3:00 pm
ICB Conference Room (Y13.01),
1300 York Ave, New York, NY 10021 United States
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Zia Khan, Ph.D. Assistant Professor University of Maryland, College Park Center for Bioinformatics and Computational Biology (CBCB)   Understanding how genetic differences affect phenotypic variation within and between species is a central goal of evolutionary and medical genetics. In this talk, I present two stories related to this important goal. The first is a study of mRNA expression and protein abundance divergence between human, chimpanzee, and rhesus macaque lymphoblastoid cell…

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Computational Systems Biology Approaches to Investigate Mechanisms of Progression and Therapeutic Response in Human Cancer

June 11, 2015 @ 4:00 pm - 5:00 pm
Physiology Conference Room (LC-504),
1300 York Ave, New York, NY 10065 United States
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Antonina Mitrofanova, Ph.D. Associate Research Scientist Irving Cancer Research Center Columbia University   Hosted by Olivier Elemento, Ph.D.

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Experiments with MetaR and a Composable R Language Blend User Interfaces and Scripting for More Productive and Accessible Data Analysis

June 12, 2015 @ 4:00 pm - 5:00 pm
ICB Conference Room (Y13.01),
1300 York Ave, New York, NY 10021 United States
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Fabien Campagne, Ph.D.   Hosted by Trine Krogh-Madsen, Ph.D.

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July 2015

CAPRI: Efficient Inference of Selective Advantage Relationships in Cancer Progression

July 9, 2015 @ 2:00 pm - 3:00 pm
ICB Conference Room (Y13.01),
1300 York Ave, New York, NY 10021 United States
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Marco Antoniotti, Ph.D. Associate Professor Dipartimento Informatica Sistemistica e Comunicazione Universit√† Milano Bicocca   Joint work with: Daniele Ramazzotti, Giulio Caravagna, Loes Olde Loohuis, Ilya Korsunsky, Giancarlo Mauri, Bud Mishra   Abstract: Cancer is a disease of evolution whose process is characterized by the accumulation of somatic alterations to the genome, which selectively make a cancer cell fitter to survive. The understanding of progression models for cancer, i.e., the identification…

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Temporal Patterns of Short Non-Coding RNA Modifications and Expression

July 10, 2015 @ 2:00 pm - 3:00 pm
ICB 13th Floor Conference Room,
1305 York Avenue, New York, NY 10021 United States
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Ammar Naqvi, PhD Student Grigoriev Lab Center for Computational and Integrative Biology Rutgers University   Hosted by Ekta Khurana, Ph.D.

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September 2015

Regulatory Signaling Nodes in Vascular Homeostasis Revealed by a Transposon Mutagenesis Screen

September 9, 2015 @ 4:00 pm - 5:00 pm
Weill Auditorium C-200,
1300 York Avenue, 2nd Floor, NewYork City, NY 10065 United States
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Luisa Iruela-Arispe, Ph.D. Professor and Vice-Chair Dept. of Molecular, Cell and Dev. Biology – UCLA Director, Molecular Biology Institute Chair, Molecular Biology IDP   Hosted by Carl Blobel, M.D., Ph.D.

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Reconstructing the Evolutionary History of Tumours

September 10, 2015 @ 2:00 pm - 3:00 pm
Physiology Conference Room (LC-504),
1300 York Ave, New York, NY 10065 United States
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Quaid Morris, PhD Associate Professor, Banting and Best Department of Medical Research Departments of Molecular Genetics and Computer Science Toronto ON, Canada   Hosted by Ekta Khurana, Ph.D.

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The Canon of Cancer Medicine

September 14, 2015 @ 11:00 am - 12:00 pm
Physiology Conference Room (LC-504),
1300 York Ave, New York, NY 10065 United States
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Bud Mishra Prof of CS and Math, Courant Inst. The dream of a powerful integrated computational framework, only hinted at in Ibn Sina’s Canon, can now be fulfilled at a global scale as a result of many recent advances: foundational advances in statistical inference; hypothesis-driven experiment design and analysis and the dissemination of peer-reviewed publications among communities of scientists; distributed large-scale databases of scientific and auxiliary experimental data; algorithmic approaches…

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In the Midst of a Revolution: The Advent of Computational Pathology and its Impact on Clinical Practice and Biomedical Research

September 14, 2015 @ 4:00 pm - 5:00 pm
Physiology Conference Room (LC-504),
1300 York Ave, New York, NY 10065 United States
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Thomas J. Fuchs, Dr.Sc. Associate Faculty Member Memorial Sloan Kettering Cancer Center Head of Computational Pathology Lab Department of Medical Physics, MSK Department of Pathology, MSK Computational Biology Center, SKI   Hosted by Harel Weinstein, D.Sc.

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Integrating Multiple Sequence Signals to Unravel Cancer Genome Structure

September 18, 2015 @ 4:00 pm - 5:00 pm
ICB Conference Room (Y13.01),
1300 York Ave, New York, NY 10021 United States
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Marcin Imielinski, M.D., Ph.D.   Hosted by Trine Krogh-Madsen, PhD

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