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Regulatory Variation from RNA to Protein in Humans and Primates
Zia Khan, Ph.D. Assistant Professor University of Maryland, College Park Center for Bioinformatics and Computational Biology (CBCB) Understanding how genetic differences affect phenotypic variation within and between species is a central goal of evolutionary and medical genetics. In this talk, I present two stories related to this important goal. The first is a study of mRNA expression and protein abundance divergence between human, chimpanzee, and rhesus macaque lymphoblastoid cell…
Find out more »Computational Systems Biology Approaches to Investigate Mechanisms of Progression and Therapeutic Response in Human Cancer
Antonina Mitrofanova, Ph.D. Associate Research Scientist Irving Cancer Research Center Columbia University Hosted by Olivier Elemento, Ph.D.
Find out more »CAPRI: Efficient Inference of Selective Advantage Relationships in Cancer Progression
Marco Antoniotti, Ph.D. Associate Professor Dipartimento Informatica Sistemistica e Comunicazione Università Milano Bicocca Joint work with: Daniele Ramazzotti, Giulio Caravagna, Loes Olde Loohuis, Ilya Korsunsky, Giancarlo Mauri, Bud Mishra Abstract: Cancer is a disease of evolution whose process is characterized by the accumulation of somatic alterations to the genome, which selectively make a cancer cell fitter to survive. The understanding of progression models for cancer, i.e., the identification…
Find out more »Temporal Patterns of Short Non-Coding RNA Modifications and Expression
Ammar Naqvi, PhD Student Grigoriev Lab Center for Computational and Integrative Biology Rutgers University Hosted by Ekta Khurana, Ph.D.
Find out more »Reconstructing the Evolutionary History of Tumours
Quaid Morris, PhD Associate Professor, Banting and Best Department of Medical Research Departments of Molecular Genetics and Computer Science Toronto ON, Canada Hosted by Ekta Khurana, Ph.D.
Find out more »The Canon of Cancer Medicine
Bud Mishra Prof of CS and Math, Courant Inst. The dream of a powerful integrated computational framework, only hinted at in Ibn Sina’s Canon, can now be fulfilled at a global scale as a result of many recent advances: foundational advances in statistical inference; hypothesis-driven experiment design and analysis and the dissemination of peer-reviewed publications among communities of scientists; distributed large-scale databases of scientific and auxiliary experimental data; algorithmic approaches…
Find out more »Characterization of Hybrid Incompatibility Genes in Drosophila
Tawny Cuykendall Department of Molecular Biology & Genetics Cornell University Hosted by Ekta Khurana, Ph.D.
Find out more »Bioinformatics at the NIHR Maudsley Biomedical Research Centre and the SLaM-IoPPN Centre for Translational Informatics: A quick Tour
Dr. Stephen J Newhouse Senior Bioinformatician Social Genetic & Developmental Psychiatry Kings College, London, UK Our research is focused on translational bioinformatics and “Harnessing ‘big biomedical data’ for better clinical care”. We complement the strategic goals of the BRC/U by facilitating the integration of clinical data from patient records with large biological datasets. The biological data involved derives from disease-focused studies of transcriptomics, genomics, epigenetics, proteomics and neuroimaging. This…
Find out more »Learning the ‘Metadata’ of the Cell – Inferring Cellular Phenotypes with Single-Cell Genomics
Rahul Satija, D.Phil. Assistant Professor of Biology New York University Department of Biology Center for Genomics and Systems Biology Hosted by Drs. Doron Betel and Olivier Elemento
Find out more »Multiplatform Analysis of Molecular Heterogeneity in Cancer
Ronglai Shen, Ph.D. Assistant Attending Biostatistician Memorial Sloan-Kettering Cancer Center Department of Epidemiology and Biostatistics Hosted by Drs. Doron Betel and Olivier Elemento
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