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June 2015

Chalkboard to Bedside: Translating Insights from Multiscale Evolutionary Mathematical Models to the Clinic

June 3, 2015 @ 11:00 am - 12:00 pm
Physiology Conference Room (LC-504),
1300 York Ave, New York, NY 10065 United States
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Jacob Scott, M.D. Department of Radiation Oncology and Integrative Mathematical Oncology H. Lee Moffitt Cancer Center and Oxford University Centre for Mathematical Biology   Hosted by Harel Weinstein, D.Sc.

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Regulatory Variation from RNA to Protein in Humans and Primates

June 8, 2015 @ 2:00 pm - 3:00 pm
ICB Conference Room (Y13.01),
1300 York Ave, New York, NY 10021 United States
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Zia Khan, Ph.D. Assistant Professor University of Maryland, College Park Center for Bioinformatics and Computational Biology (CBCB)   Understanding how genetic differences affect phenotypic variation within and between species is a central goal of evolutionary and medical genetics. In this talk, I present two stories related to this important goal. The first is a study of mRNA expression and protein abundance divergence between human, chimpanzee, and rhesus macaque lymphoblastoid cell…

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Computational Systems Biology Approaches to Investigate Mechanisms of Progression and Therapeutic Response in Human Cancer

June 11, 2015 @ 4:00 pm - 5:00 pm
Physiology Conference Room (LC-504),
1300 York Ave, New York, NY 10065 United States
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Antonina Mitrofanova, Ph.D. Associate Research Scientist Irving Cancer Research Center Columbia University   Hosted by Olivier Elemento, Ph.D.

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July 2015

CAPRI: Efficient Inference of Selective Advantage Relationships in Cancer Progression

July 9, 2015 @ 2:00 pm - 3:00 pm
ICB Conference Room (Y13.01),
1300 York Ave, New York, NY 10021 United States
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Marco Antoniotti, Ph.D. Associate Professor Dipartimento Informatica Sistemistica e Comunicazione Università Milano Bicocca   Joint work with: Daniele Ramazzotti, Giulio Caravagna, Loes Olde Loohuis, Ilya Korsunsky, Giancarlo Mauri, Bud Mishra   Abstract: Cancer is a disease of evolution whose process is characterized by the accumulation of somatic alterations to the genome, which selectively make a cancer cell fitter to survive. The understanding of progression models for cancer, i.e., the identification…

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Temporal Patterns of Short Non-Coding RNA Modifications and Expression

July 10, 2015 @ 2:00 pm - 3:00 pm
ICB 13th Floor Conference Room,
1305 York Avenue, New York, NY 10021 United States
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Ammar Naqvi, PhD Student Grigoriev Lab Center for Computational and Integrative Biology Rutgers University   Hosted by Ekta Khurana, Ph.D.

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September 2015

Reconstructing the Evolutionary History of Tumours

September 10, 2015 @ 2:00 pm - 3:00 pm
Physiology Conference Room (LC-504),
1300 York Ave, New York, NY 10065 United States
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Quaid Morris, PhD Associate Professor, Banting and Best Department of Medical Research Departments of Molecular Genetics and Computer Science Toronto ON, Canada   Hosted by Ekta Khurana, Ph.D.

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The Canon of Cancer Medicine

September 14, 2015 @ 11:00 am - 12:00 pm
Physiology Conference Room (LC-504),
1300 York Ave, New York, NY 10065 United States
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Bud Mishra Prof of CS and Math, Courant Inst. The dream of a powerful integrated computational framework, only hinted at in Ibn Sina’s Canon, can now be fulfilled at a global scale as a result of many recent advances: foundational advances in statistical inference; hypothesis-driven experiment design and analysis and the dissemination of peer-reviewed publications among communities of scientists; distributed large-scale databases of scientific and auxiliary experimental data; algorithmic approaches…

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October 2015

Characterization of Hybrid Incompatibility Genes in Drosophila

October 14, 2015 @ 10:00 am - 11:00 am
ICB 13th Floor Conference Room,
1305 York Avenue, New York, NY 10021 United States
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Tawny Cuykendall Department of Molecular Biology & Genetics Cornell University   Hosted by Ekta Khurana, Ph.D.

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Bioinformatics at the NIHR Maudsley Biomedical Research Centre and the SLaM-IoPPN Centre for Translational Informatics: A quick Tour

October 14, 2015 @ 11:00 am - 12:00 pm
Physiology Conference Room (LC-504),
1300 York Ave, New York, NY 10065 United States
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Dr. Stephen J Newhouse Senior Bioinformatician Social Genetic & Developmental Psychiatry Kings College, London, UK   Our research is focused on translational bioinformatics and “Harnessing ‘big biomedical data’ for better clinical care”. We complement the strategic goals of the BRC/U by facilitating  the integration of clinical data from patient records with large biological datasets. The biological data involved derives from disease-focused studies of transcriptomics, genomics, epigenetics, proteomics and neuroimaging. This…

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Learning the ‘Metadata’ of the Cell – Inferring Cellular Phenotypes with Single-Cell Genomics

October 26, 2015 @ 11:00 am - 12:00 pm
Physiology Conference Room (LC-504),
1300 York Ave, New York, NY 10065 United States
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Rahul Satija, D.Phil. Assistant Professor of Biology New York University Department of Biology Center for Genomics and Systems Biology   Hosted by Drs. Doron Betel and Olivier Elemento

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