CLUSTAL W (1.81) multiple sequence alignment CB1R_MOUSE MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE 60 CB1R_RAT MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE 60 CB1R_HUMAN MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE 60 CB1R_FELCA MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE 60 CB1R_POEGU MKSILDGLADTTFRTITTDLLYVGSNDIQYEDMKGDMASKLGYYPQKFPLSSFRGDPFQE 60 CB1R_TARGR MKSILDGLADTTFRTITTDLLYMGSNDVQYEDTKGEMASKLGYFPQKLPLSSFRRDHSPD 60 CB1A_FUGRU MKSVLDGVADTTFRTITSGLQYLGSNDANYDDPLNDAAFKTGFSLQK-PLSAFRSNSFPN 59 CB1B_FUGRU MKLALHRIAGATMAALTTEVQYLGSNDASYEDPQADAALMKSRFNFEKPYSAS--SSLHR 58 CB2R_MOUSE -------MEGCRETEVTN-----GSNGGLEFNP--------------------------- 21 CB2R_RAT -------MEGCRELELTN-----GSNGGLEFNP--------------------------- 21 CB2R_HUMAN -------MEECWVTEIAN-----GSKDGLDSNP--------------------------- 21 : ::. **:. : CB1R_MOUSE KMTAGDNSPL--VPAGDTTNITEFYNKSLSSFKENEDNIQCGENFMD-MECFMILNPSQQ 117 CB1R_RAT KMTAGDNSPL--VPAGDTTNITEFYNKSLSSFKENEENIQCGENFMD-MECFMILNPSQQ 117 CB1R_HUMAN KMTAGDNPQL--VPA-DQVNITEFYNKSLSSFKENEENIQCGENFMD-IECFMVLNPSQQ 116 CB1R_FELCA KMTAGDNSQL--VPA-DQVNITEFYNKSLSSYKENEENIQCGENFMD-MECFMILNPSQQ 116 CB1R_POEGU KMTGGDDSLLSIIPS-EQVNITEFYNKSLSTFKDNEENIQCGENFMD-MECFMILNPSQQ 118 CB1R_TARGR KMTIGDDNLLSFYPL-DQFNVTEFFNRSVSTFKENDDNLKCGENFMD-MECFMILTASQQ 118 CB1A_FUGRU KVPADEELIFKGIPF-FPTNSTDLFGNRNTTRDEN--SIQCGENFMD-MECFMILTPSQQ 115 CB1B_FUGRU LIPGNKELIYGGLSTILPTNASDFPLSNGSG-----EATQCGEDIVDNMECFMILTPAQQ 113 CB2R_MOUSE ------------------------------------------------MKEYMILSSGQQ 33 CB2R_RAT ------------------------------------------------MKEYMILSDAQQ 33 CB2R_HUMAN ------------------------------------------------MKDYMILSGPQK 33 :: :*:*. *: CB1R_MOUSE LAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVD 177 CB1R_RAT LAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVD 177 CB1R_HUMAN LAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFID 176 CB1R_FELCA LAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVD 176 CB1R_POEGU LAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVD 178 CB1R_TARGR LIIAVLSLTLGTFTVLENFLVLCVILQSRTLRCRPSYHFIGSLAVADLLGSVIFVYSFLD 178 CB1A_FUGRU LAVAVLSLTLGTFTVLENLVVLCVIFQSRTLRCRPSYHFIGSLAVADLLGSVIFVYSFLD 175 CB1B_FUGRU LVIVILAITLGTFTVLENFVVLCVILHSHTLRSRPSYHFIGSLAVADLIGSIIFVYSFLD 173 CB2R_MOUSE IAVAVLCTLMGLLSALENMAVLYIILSSRRLRRKPSYLFISSLAGADFLASVIFACNFVI 93 CB2R_RAT IAVAVLCTLMGLLSALENVAVLYLILSSQRLRRKPSYLFIGSLAGADFLASVIFACNFVI 93 CB2R_HUMAN TAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVN 93 :.:*. :* ::.***. ** :*: *: ** :*** **.*** **::.*::*. .*: CB1R_MOUSE FHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVA 237 CB1R_RAT FHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVA 237 CB1R_HUMAN FHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVA 236 CB1R_FELCA FHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKKIVTRPKAVVA 236 CB1R_POEGU FHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVA 238 CB1R_TARGR FHVFHRKDSSNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRTKAVIA 238 CB1A_FUGRU FHVFHKKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYRRIVTRTKAVIA 235 CB1B_FUGRU FHVLHRKDSPSIFLFKLAGVIASFTASVGSLFLTAIDRYVSIHRPMAYKRIITKTKAVIA 233 CB2R_MOUSE FHVFHGVDSNAIFLLKIGSVTMTFTASVGSLLLTAVDRYLCLCYPPTYKALVTRGRALVA 153 CB2R_RAT FHVFHGVDSRNIFLLKIGSVTMTFTASVGSLLLTAVDRYLCLCYPPTYKALVTRGRALVA 153 CB2R_HUMAN FHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVT 153 ***:* ** :**:*:..* :********:***:***:.: * :*: ::*: :*::: CB1R_MOUSE FCLMWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMY 297 CB1R_RAT FCLMWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMY 297 CB1R_HUMAN FCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMY 296 CB1R_FELCA FCLMWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMY 296 CB1R_POEGU FCVMWTIAIVIAVLPLLGWNCKKLNSVCSDIFPLIDETYLMFWIGVTSILLLFIVYAYMY 298 CB1R_TARGR FCVMWTIAIIIAVLPLLGWNCKKLKSVCSDIFPLIDENYLMFWIGVTSILLLFIVYAYVY 298 CB1A_FUGRU FCMMWTISIIIAVLPLLGWNCKRLNSVCSDIFPLIDENYLMFWIGVTSVLVLFIIYAYIY 295 CB1B_FUGRU FSVMWAISIEFSLLPLLGWNCKRLHSVCSDIFPLIDEKYLMFWIGMTTVLLLFIIYAYMF 293 CB2R_MOUSE LCVMWVLSALISYLPLMGWTCCPSP--CSELFPLIPNDYLLGWLLFIAILFSGIIYTYGY 211 CB2R_RAT LGVMWVLSALISYLPLMGWTCCPSP--CSELFPLIPNDYLLGWLLFIAILFSGIIYTYGY 211 CB2R_HUMAN LGIMWVLSALVSYLPLMGWTCCPRP--CSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGH 211 : :**.:: .: ***:**.* **::** * : **: *: . :.*. *:*:* . CB1R_MOUSE ILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICW 357 CB1R_RAT ILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICW 357 CB1R_HUMAN ILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICW 356 CB1R_FELCA ILWKAHIHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICW 356 CB1R_POEGU ILWKAHSHAVRMLQRGTQKSIIIQSTEDGKVQITRPDQTRMDIRLAKTLVLILVVLIICW 358 CB1R_TARGR ILWKAHSHAVRMLQRGTQKSIIIHTSEDGKVQITRPEQTRMDIRLAKTLVLILVVLIICW 358 CB1A_FUGRU ILWKAHHHAVRMLSRTSQKSLVVYSAEGTKVQTTRPEQTRMDIRLAKTLVLILAVLVICW 355 CB1B_FUGRU ILWKSHHHAVRMLSRSSQRSIIVYTSEGTKVQTVRPEQARMDLRLAKTLVLILVALIICW 353 CB2R_MOUSE VLWKAHRHVATLAEHQDR-------------QVPGIARMRLDVRLAKTLGLVLAVLLICW 258 CB2R_RAT VLWKAHQHVASLTEHLDR-------------QVPGIARMRLDVRLAKTLGLVMAVLLICW 258 CB2R_HUMAN VLWKAHQHVASLSGHQDR-------------QVPGMARMRLDVRLAKTLGLVLAVLLICW 258 :***:* *.. : : : * : *:*:****** *::..*:*** CB1R_MOUSE GPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCE 417 CB1R_RAT GPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCE 417 CB1R_HUMAN GPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCE 416 CB1R_FELCA GPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCE 416 CB1R_POEGU GPLLAIMVYDVFGKMNKLIKTIFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPTCE 418 CB1R_TARGR GPLLAIMVYDVFGKMNNPIKTVFAFCSMLCLMDSTVNPIIYALRSQDLRHAFLEQCPPCE 418 CB1A_FUGRU GPLLAIMVYDLFWKMDDNIKTVFAFCSMLCLLNSTVNPIIYALRSRDLRHAFLSSCHACR 415 CB1B_FUGRU GPLLAIMVYDLFGRVNDFIKTVFAFCSMLCLLNSTINPVIYAMRSKDLRRAFVNICHMCR 413 CB2R_MOUSE FPALALMGHSLVTTLSDQVKEAFAFCSMLCLVNSMVNPIIYALRSGEIRSAAQHCLIGWK 318 CB2R_RAT FPALALMGHSLVTTLSDKVKEAFAFCSMLCLVNSMVNPIIYALRSGEIRSAAQHCLTGWK 318 CB2R_HUMAN FPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWK 318 * **:* :.: :.. :* *********::* :**:***:** ::* : . CB1R_MOUSE GTAQPLDNSMGDSDCLHKHANNT-ASMHRAAESCIKSTVKIAKVTMS-VSTDTSAEAL 473 CB1R_RAT GTAQPLDNSMGDSDCLHKHANNT-ASMHRAAESCIKSTVKIAKVTMS-VSTDTSAEAL 473 CB1R_HUMAN GTAQPLDNSMGDSDCLHKHANNA-ASVHRAAESCIKSTVKIAKVTMS-VSTDTSAEAL 472 CB1R_FELCA GTAQPLDNSMGDSDCLHKHANNT-ANVHRAAENCIKNTVQIAKVTIS-VSTNTSAKAL 472 CB1R_POEGU GTAQPLDNSM-ESDCQHKHANNA-GNVHRAAESCIKSTVKIAKVTMS-VSTDTTAEAL 473 CB1R_TARGR GTSQPLDNSM-ESDCQHRHGNNA-GNVHRAAENCIKSTVKIAKVTMS-VSTETSGEAV 473 CB1A_FUGRU GSAQQLDNSL-ESDCQNRNVN---ISANRAAESCVKTTVKIAKVTMS-VSTETSAEAV 468 CB1B_FUGRU GTTQSLDSSA-ESDWNSRSVRSTGGRAGKDRSVGGKPQVKVAQVTVSGVTASSPAEAV 470 CB2R_MOUSE KYLQGLGPEG----------------KEEGPRSSVTETEADVKTT------------- 347 CB2R_RAT KYLQGLGSEG----------------KEEAPKSSVTETEAEVKTTTGPGSRTPGCSNC 360 CB2R_HUMAN KCVRGLGSEA----------------KEEAPRSSVTETEADGKITPWPDSRDLDLSDC 360 : *. . . . : *