[ description ]

sp-NMR is an information system to support the design of selective, high affinity inhibitors of the binding of HIV Tat protein to the P/CAF Bromodomain. To facilitate data sharing and collaborations on this research project, SP-NMR offers information obtained when conducting focused NMR compound binding assays and presents an integrated view of the data to inform the rational drug-design process.

The goals of sp-NMR are to:

Support investigators conducting NMR-based drug-design studies;

Integrate diverse experimental results and data types produced by these studies;

Foster information sharing among investigators studying the binding of HIV Tat and PCAF;

Provide a central, web-accessible data repository;

Standardize data collection procedures and provide quality control.

[ contacts ]

[ availability ]

Access to sp-NMR is currently restricted to members of the NIH-AIDS Program Project Grant (PI Zhou, Ming-Ming). To obtain the login and password information needed to access sp-NMR, please contact us. When you have obtained login and password, visit sp-NMR at http://icb.med.cornell.edu/betas/sp-nmr/mmzdb/

We are in the process of setting up a public instance of sp-NMR that will offer published data. Data will be migrated from the NIH-AIDS PPG instance to the public instance of sp-NMR as soon as the manuscripts that the data supports are accepted for publication.

Download for Local Installation

sp-NMR is distributed under the GNU General Public License (GPL) and requires a backend JDO compliant database and a servlet container. sp-NMR relies extensively on code from the SigPath project. Installation procedures are similar to those of SigPath. Please contact us if you need assistance installing a local instance of sp-NMR.

source code [23.1MB, September 12th 2005]

JavaDocs

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